Mr. Bisignano, a former Wall Street executive, will lead an agency upended by big staff cuts and other significant changes.

The Senate voted on Tuesday to confirm Frank Bisignano as commissioner of the Social Security Administration, which has been thrown into turmoil after a three-month stretch steered largely by Elon Musk’s unofficial Department of Government Efficiency.

President Trump’s nominee was confirmed by a vote of 53 to 47, which had been expected and was split along party lines.

Mr. Bisignano, a former Wall Street executive, will take the helm at a critical juncture. A series of recent changes led by DOGE, including deep job cuts and a move to manipulate sensitive databases, have rattled current and former employees, former commissioners of both parties, beneficiaries and their advocates. They have been alarmed by the fast and seemingly haphazard shifts, as well as the departure from established protocols that protect beneficiaries’ privacy and ensure they

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